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pentobarbital will lessen the level or effect of darunavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.Observe Closely (2)pentobarbital will lessen the level or effect of buprenorphine, long-acting injection by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Closely. Clients who